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| Fig. 44.5 A, Squamous cell carcinoma in situ presenting a scaly plaque on the groin. B, Squamous cell carcinoma of the penis (erythroplasia of Queyrat) presenting as an erythematous, minimally indurated plaque. |
Bowen’s disease is an older term for squamous cell carcinoma in situ (Fig. 44-5A). Clinically, SCC in situ presents as persistent, erythematous, slightly indurated plaques with variable scale. It may resemble superficial spreading BCC, Paget’s disease, or various inflammatory skin conditions. SCC in situ occurring on the male genitalia has also been described under the name
erythroplasia of Queyrat and may be associated with human papillomavirus infection (Fig. 44-5B). Microscopically, squamous cell carcinoma in situ demonstrates full-thickness cytologic atypia of the keratinocytes without invasion through the basement membrane.
