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| Fig. 47.3 Middle-aged woman with a typical microcystic adnexal carcinoma. |
MAC is a locally aggressive tumor that shows histologic evidence of follicular and sweat duct differentiation. It classically presents as a slow-growing, firm, ill-defined plaque or nodule on the head and neck, most often on the upper lip (Fig. 47-3). Numbness, paresthesia, burning, discomfort, or, rarely, pruritus of the affected area may be reported, and are likely related to the fact that the tumor frequently exhibits perineural invasion. Histologically, it must be differentiated from morpheaform basal cell carcinoma, desmoplastic trichoepithelioma, or syringoma.
Wetter R, Goldstein GD: Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge,
Dermatol Ther 21:452–458, 2008.
