Are there contraindications to cryosurgery?

People with cold-related conditions, such as cryoglobulinemia, cryofibrinogenemia, cold urticaria, and Raynaud’s disease, should not be treated with cryosurgery. Patients with heavily pigmented skin should be treated with caution because they are more likely to heal with hyperpigmented or hypopigmented scars, due to the sensitivity of melanocytes to freezing. In addition, the use of cryosurgery in hair-bearing areas may result in alopecia.