Bone marrow-derived dendritic cell with monocyte-macrophage lineage found in stratum spinosum; constitutes 3–5% of cells of epidermis; contains actin and vimentin
Critical in recognizing and presenting foreign antigens to specific T lymphocytes
Connected to keratinocytes via E-cadherin receptors
On EM, Langherhans cell with folded nucleus and distinct intracytoplasmic organelles (Birbeck granules: rod-shaped or tennis racquet-shaped with striated appearance)
Exposure to UV radiation causes depletion of LC and decreases ability to present antigen
