Actinic Keratosis | Figure 5.6
A: Syringomas
(Courtesy of Dr. Paul Getz)
B: Cutaneous leiomyomas
(Reprint from Bolognia JL,
Rapini R, Jorrizo JL.
Dermatology. 2nd ed.
St. Louis, MO: Mosby; 2008)
C: Actinic keratosis |
- Common premalignant lesion in sun-exposed areas with potential to transform into squamous cell carcinoma (percentage varies)
- Presents as erythematous macule or thin papule with adherent scale in sun-exposed areas (easier to identify with palpation)
- Histology: focal parakeratosis, atypical keratinocytes with nuclear pleomorphism and crowding (partial-thickness dysplasia), disordered maturation, prominent solar elastosis in dermis
- Variants: pigmented AK, acantholytic AK, bowenoid AK, lichenoid AK, atrophic AK, hypertrophic AK, actinic cheilitis (confluence of AKs typically on lower lip), cutaneous horn (conical excrescence)
- Treatment: cryotherapy, topical 5-fluorouracil (5-FU), topical imiquimod, chemical peels, photodynamic therapy (PDT)
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