Angiosarcoma

Figure 5.14
A: Angiosarcoma
(Reprint from Morgan MB,
Smoller BR, Somach SC.
Deadly Dermatologic Diseases.
New York, NY: Springer; 2007)
B: Sebaceous carcinoma
(Reprint from Markman M, ed.
Atlas of Cancer. Philadelphia:
Current Medicine Inc; 2002)

(Figure 5.14A)

Very aggressive but rare tumor presenting as violaceous plaque on face or scalp; may be solitary or multiple and most often see in elderly men; metastasis seen in lymph nodes, lungs, spleen, and liver
Angiosarcoma may occur in presence of chronic lymphedema; Stewart- Treves syndrome: angiosarcoma occurring in area of long-standing chronic lymphedema (lymphedema often resulting from radical mastectomy to treat breast cancer)
Histology: poorly demarcated tumor consisting of dissecting vascular spaces with large pleomorphic, hyperchromatic endothelial cells, extravasated red blood cells, + CD31, + CD34, + factor VIII–related antigen
Poor prognosis; treat with wide surgical excision but high rate of recurrence, ± adjunctive radiation therapy

Content

Angiosarcoma