Anticoagulant-Induced Skin Necrosis- Rare reaction typically seen 2–5 days after offending drug started; typically due to warfarin or heparin; likely related to drop in protein C level
- Present with painful erythematous plaque that turn into necrotic ulcers and or bullae due to ischemic infarcts; typically seen on buttocks, thighs, or breasts
- Treatment: stop offending drug, vitamin K, IV concentrate of protein C
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