| Table 8-9 Characteristic Histologic Bodies |
| | Histologic Body | | Description | | Entity |
| | Antoni A tissue | | Cellular pattern (spindle cells arranged in stacks with palisading nuclei) with Verocay bodies | | Schwannoma |
| | Antoni B tissue | | Hypocellular pattern: loose stroma and few cells | | Schwannoma |
| | Asteroid bodies | | Extracellular central spore surrounded by radiating homogenous eosinophilic material | | Sporotrichosis
(Splendore-Hoeppli phenomenon) |
| | | Intracellular stellate eosinophilic inclusion bodies within multinucleated giant cell | | Sarcoidosis, berylliosis, foreign body reaction, etc. |
| | Banana bodies | | Banana-shaped golden-yellow (ochre) fibers | | Ochronosis |
| | Bean bag cells | | Histiocytes showing phagocytosis of lymphocytes, erythrocytes, or platelets | | Cytophagic histiocytic panniculitis |
| | Birbeck granules | | Tennis racket–shaped or rod-shaped structures within cytoplasm of Langerhans cell seen on EM | | Langerhans cell histiocytosis |
| | Caterpillar bodies | | Wavy eosinophilic material in basal epidermal layer or roof of blister | | Porphyria cutanea tarda, erythropoietic porphyria |
| | Cholesterol clefts | | Lipid crystals inside adipocytes forming rosettes of needle-like clefts | | Sclerema neonatorum, subcutaneous fat necrosis of newborn |
| | | Clear needle-shaped spaces
(not necessarily in adipocytes) | | Xanthomas, necrobiotic xanthogranuloma |
| | Colloid bodies
(Civatte bodies) | | Eosinophilic homogenous structures (cell remnants) in lower epidermis or papillary dermis | | Lichen planus, other interface dermatoses |
| | Corp ronds | | Dyskeratotic acantholytic keratinocytes with round nuclei and perinuclear halo | | Darier’s disease, Hailey-Hailey, Grover’s disease, warty dyskeratoma |
| | Cowdry Type A inclusion bodies | | Large eosinophilic intranuclear inclusion with surrounding clear halo in infected cells | | HSV and VZV infection |
| | Cowdry Type B inclusion bodies | | Intranuclear amorphous bodies surrounded by clear halo
in neural cells | | Polio |
| | Donovan bodies | | Intracytoplasmic bacteria in infected histiocytes
(vacuolated appearance containing bacilli) | | Granuloma inguinale |
| | Dutcher bodies | | Eosinophilic intranuclear inclusions of immunoglobulins in malignant plasma cells | | Multiple myeloma |
| | Flame figures | | Eosinophilic material (cells and debris) surrounding pink amorphous collagen | | Well’s syndrome, arthropod bite, drug reaction |
| | Floret-type giant cell | | Giant cells with eosinophilic cytoplasm and marginally placed nuclei resembling small flower | | Pleomorphic lipoma |
| | Globi | | Foamy histiocytes containing clustered bacilli | | Lepromatous leprosy |
| | Gamma Favre body | | Large intracytoplasmic basophilic inclusion body | | Lymphogranuloma venereum |
| | Gargoyle cells | | Fibroblast with large deposits of mucopolysaccharide (MPS) | | MPS storage diseases
(i.e., Hurler) |
| | Grains | | Basophilic dyskeratotic cells with elongated wavy or “grain-shaped” nuclei in granular layer | | Darier’s disease, Hailey-Hailey, Grover’s disease, warty dyskeratoma |
| | Guarnieri bodies | | Eosinophilic cytoplasmic inclusions in affected epithelial cells | | Vaccinia or smallpox |
| | Henderson-Patterson bodies | | Large eosinophilic cytoplasmic inclusion of viral protein
in keratinocytes | | Molluscum contagiosum |
| | Kamino bodies | | Eosinophilic amorphous globules (contain basement membrane component) | | Spitz nevi |
| | Koilocytes | | Keratinocyte with hyperchromatic nuclei surrounded by perinuclear halo | | HPV infection |
| | Langhans giant cells | | Multinucleated giant cell with nuclei arranged peripherally in a horseshoe-shaped pattern (unlike foreign body giant cells with haphazard pattern) | | Sarcoidosis, tuberculosis |
| | Lipofuscin granules | | Lipofuscin yellow-brown granule accumulation in dermal macrophages | | Amiodarone pigmentation |
| | Max Joseph space | | Artifactual clefting at dermo-epidermal junction | | Lichen planus |
| | Medlar bodies
(Copper pennies) | | Thick-walled spherical brown cells | | Chromomycosis |
| | Miescher’s radial granuloma | | Nodules containing histiocytes arranged radially around central cleft in interlobular septae | | Erythema nodosum |
| | Miescher’s granuloma | | Phagocytosis of dermal elastic fibers by giant cells and histiocytes | | Annular elastolytic giant cell
granuloma
(actinic granuloma) |
| | Michaelis Gutmann bodies | | Concentric basophilic lamellar bodies in foamy macrophages (von Hansemann) in urinary tract | | Malakoplakia |
| | Mikulicz cell | | Foamy macrophage containing bacilli | | Rhinoscleroma |
| | Mariner’s wheel | | Budding yeast resemble “mariner’s wheel” | | Paracoccidioidomycosis |
| | Mulberry cells | | Multiple septations with mulberry-like sporangia | | Protothecosis, hibernoma |
| | Munro microabscess | | Small collection of neutrophils within horny layer associated with parakeratosis | | Psoriasis |
| | Negri bodies | | Neuronal eosinophilic bodies | | Rabies |
| | Pautrier microabscesses | | Collection of atypical T cells within epidermis | | Cutaneous T-cell lymphoma |
| | Psammoma body | | Concentrically laminated collection of calcium | | Meningioma |
| | Pustulo-ovoid bodies | | Round eosinophilic cytoplasmic inclusion | | Granular cell tumor |
| | Rocha-Lima bodies | | Pink-purple cytoplasmic inclusion in endothelial cells | | Oroya fever/verruga peruana |
| | Russell bodies | | Eosinophilic immunoglobulin deposits within plasma cell | | Rhinoscleroma, granuloma inguinale |
| | Verocay body | | Parallel rows of nuclei surrounded by homogenous eosinophilic material | | Schwannoma |
| | Schaumann bodies | | Calcified inclusion from degenerated lysosomes in macrophages | | Sarcoidosis |
| | Virchow cells | | Foamy histiocytes containing M. leprae | | Lepromatous leprosy |
| | Von Hansemann cells | | Foamy eosinophilic macrophages containing Michaelis Gutmann bodies | | Malakoplakia |
| | | | | | |
