Histopathologic Findings

   
 
Table 8-11 Differential Diagnosis
 FindingSeen in:
 
Deep lesion
(no epidermis/upper dermis seen)
Rheumatoid nodule, malignant fibrous histiocytoma, neurothekeoma, paraffinoma, giant cell tumor of tendon sheath, nodular fasciitis, myxoid liposarcoma, angiolipoma, angioleiomyoma, ± neurilemmoma, gout, hibernoma
 
Painful tumors: BLEND AN EGG
Blue rubber bleb, leiomyoma, eccrine spiradenoma, neurilemmoma, dermatofibroma, angiolipoma, neuroma, erythema nodosum, endometriosis, glomus tumor, glomangioma
 
Polypoid
Accessory tragus, digital fibrokeratoma
 
Acral
Digital fibrokeratoma, verruca, supernumerary digit, amputation neuroma, myoid cyst
 
Minimal change
Tinea versicolor, macular amyloidosis, ichthyosis vulgaris, telangiectasia macularis eruptiva perstans, vitiligo, urticaria
 
Squared off (boxcar) biopsy
Scleredema, pretibial myxedema, morphea, advanced NLD