»	How significant is the occurrence of skin disease in the setting of HIV infection?
»	Outline the clinical spectrum of cutaneous disease associated with HIV infection.
»	What are the most common dermatoses associated with HIV infection?
»	Can mucocutaneous changes occur as a result of primary HIV infection?
»	What is the most common bacterial pathogen in HIV disease? How does it manifest itself?
»	What is the most common cutaneous malignancy in HIV disease?
»	What are the cutaneous clinical features of epidemic Kaposi’s sarcoma?
»	How is Kaposi’s sarcoma treated?
»	Is the course of syphilis altered in HIV-infected individuals?
»	How does syphilis increase the risk for HIV infection?
»	What is oral hairy leukoplakia?
»	Name the four types of oropharyngeal candidiasis that can be seen in HIV disease.
»	What is HIV-associated eosinophilic folliculitis?
»	Is the incidence of drug eruptions increased in HIV disease?
»	Describe clinical features of molluscum contagiosum infection in the HIV-infected host.
»	How is molluscum contagiosum treated?
»	Is the prevalence of common and genital warts increased in HIV infection?
»	What causes bacillary angiomatosis?
»	How does varicella-zoster virus infection present in the HIV-positive patient?
»	Do any photosensitive dermatoses occur in HIV disease?
»	What is known about granuloma annulare in the setting of HIV infection?
»	Describe some of the potential cutaneous side effects of antiretroviral therapy.
»	What is the immune restoration syndrome?

Outline the clinical spectrum of cutaneous disease associated with HIV infection.

See Table 39-1.

Table 39-1. Mucocutaneous Diseases Seen in HIV Infection^*
	NEOPLASTIC DISEASES	INFECTIOUS DISEASES
	Kaposi’s sarcoma Lymphoma Squamous cell carcinoma Basal cell carcinoma	Bacterial Staphylococcus aureus infections Syphilis Bacillary angiomatosis Fungal Candida, Penicillium marneffei Dermatophytosis Cryptococcosis Histoplasmosis Viral Human papillomavirus (HPV) Molluscum contagiosum Herpes simplex virus (HSV) Varicella-zoster virus (VZV) Cytomegalovirus (CMV) Epstein-Barr virus Arthropods Scabies
	PAPULOSQUAMOUS DISEASES
	Seborrheic dermatitis Xerosis/acquired ichthyosis Psoriasis Reiter’s syndrome
	MISCELLANEOUS DISEASES
	Eosinophilic folliculitis Drug eruptions Hyperpigmentations Photoeruptions Pruritus Lipodystrophy Granuloma annulare Aphthosis
	^*Costner M, Cockerell CJ: The changing spectrum of the cutaneous manifestations of HIV disease, Arch Dermatol 134:1290–1292, 1998. Dover JS, Johnson RA: Cutaneous manifestations of human immunodeficiency virus infection: parts 1 and 2, Arch Dermatol 127:1383–1391, 1549–1558, 1991. James W, editor: AIDS: a ten-year perspective, Dermatol Clin 9:391–615, 1991.