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Cutaneous Manifestations of Aids

»How significant is the occurrence of skin disease in the setting of HIV infection?
»Outline the clinical spectrum of cutaneous disease associated with HIV infection.
»What are the most common dermatoses associated with HIV infection?
»Can mucocutaneous changes occur as a result of primary HIV infection?
»What is the most common bacterial pathogen in HIV disease? How does it manifest itself?
»What is the most common cutaneous malignancy in HIV disease?
»What are the cutaneous clinical features of epidemic Kaposi’s sarcoma?
»How is Kaposi’s sarcoma treated?
»Is the course of syphilis altered in HIV-infected individuals?
»How does syphilis increase the risk for HIV infection?
»What is oral hairy leukoplakia?
»Name the four types of oropharyngeal candidiasis that can be seen in HIV disease.
»What is HIV-associated eosinophilic folliculitis?
»Is the incidence of drug eruptions increased in HIV disease?
»Describe clinical features of molluscum contagiosum infection in the HIV-infected host.
»How is molluscum contagiosum treated?
»Is the prevalence of common and genital warts increased in HIV infection?
»What causes bacillary angiomatosis?
»How does varicella-zoster virus infection present in the HIV-positive patient?
»Do any photosensitive dermatoses occur in HIV disease?
»What is known about granuloma annulare in the setting of HIV infection?
»Describe some of the potential cutaneous side effects of antiretroviral therapy.
»What is the immune restoration syndrome?

 
 
 

What are the cutaneous clinical features of epidemic Kaposi’s sarcoma?


Kaposi’s sarcoma. Multiple violaceous papules and plaques. (Courtesy of James E. Fitzpatrick, MD.)
Fig. 39.2 Kaposi’s sarcoma. Multiple violaceous papules and plaques. (Courtesy of James E. Fitzpatrick, MD.)
Epidemic Kaposi’s sarcoma has a widespread, symmetrical distribution of rapidly progressive macules, patches, nodules, plaques, and tumors. Common areas of involvement include the trunk, extremities, face, and oral cavity. Early lesions consist of erythematous macules, patches, or papules that may have a bruiselike halo. They enlarge at different rates and tend to be oval or elongated in shape, following the lines of skin cleavage. The color varies from pink to red, purple, or brown and can easily mimic purpura, hemangiomas, nevi, sarcoidosis, pityriasis rosea, secondary syphilis, lichen planus, basal cell carcinoma, and melanoma.

The surface may become scaly, hyperkeratotic, ulcerated, or hemorrhagic. Disfigurement and pain secondary to edema can occur, especially on the face, genitals, and lower extremities. Koebnerization, or formation of new lesions at sites of trauma, can be seen. Secondary bacterial infection can also occur. Lesions can be arranged in several known patterns, such as a follicular (clustered) pattern (Fig. 39-2), pityriasis rosea–like pattern, or dermatomal pattern.