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Leukemic and Lymphomatous Infiltrates of the Skin

»	Define lymphoma.
Mycosis Fungoides
»	Is there a lymphoma that begins in the skin?
»	What type of lymphoma is mycosis fungoides?
»	How common is mycosis fungoides?
»	How does mycosis fungoides begin?
»	What is parapsoriasis?
»	What type of skin lesions are seen in patients with mycosis fungoides?
»	Describe the three subtypes of mycosis fungoides.
»	What is the TNM classification of mycosis fungoides?
»	How is mycosis fungoides treated?
»	Describe topical nitrogen mustard (HN2) therapy.
»	If a patient develops allergic contact dermatitis to topical nitrogen mustard, does the treatment have to be permanently discontinued?
»	Is photochemotherapy an effective treatment of mycosis fungoides?
»	What are the major side effects of bexarotene in the treatment of patients with cutaneous T-cell lymphoma?
»	How does one manage the side effects of bexarotene?
»	Are interferons effective in treating mycosis fungoides?
»	Is chemotherapy an effective treatment of mycosis fungoides?
»	What is extracorporeal photophoresis?
»	Are there any other FDA-approved treatments for cutaneous T-cell lymphoma?
Other Lymphomas and Leukemias
»	Outline the Ann Arbor clinical staging system for Hodgkin’s disease.
»	What is a Reed-Sternberg cell?
»	What are the histologic classes of Hodgkin’s disease?
»	Does Hodgkin’s disease occur in the skin?
»	How are cells immunophenotyped? What does the CD nomenclature mean?
»	What is lymphomatoid papulosis?
»	Are CD30-positive cells specific for lymphomatoid papulosis?
»	What is HTLV-1 virus? What is its significance?
»	Can multiple myeloma present with skin lesions only?
»	What is pseudolymphoma of the skin?
»	Can B-cell lymphomas present with skin lesions?
»	What is the most common type of leukemia in adults?
»	Can leukemia present with specific skin lesions?
»	What are some nonspecific skin lesions seen in patients with leukemia?

What is a Reed-Sternberg cell?

It is a large cell with two mirror-image nuclei with large distinct nucleoli, often with surrounding halos (owl’s eye cells). It is considered to be the malignant cell of Hodgkin’s disease, and its presence confirms the histologic diagnosis. The origin of the cell is debated, with marker studies having shown both T- and B-cell immunoenzymatic staining.