(Figure 4.35C) - Penicillium marneffei
- Carried by healthy bamboo rats
- Presents with acneiform papules resembling molluscum contagiosum (seen especially in AIDS patients)
- Histology: suppurative granulomatous inflammation with intracellular and extracellular yeast
| | | | | | Following infections may resemble molluscum-like lesions: coccidioidomycosis, cryptococcosis, histoplasmosis, penicilliosis | | | | | |
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| | | | | | Organisms found within histiocytes: histoplasmosis, granuloma inguinale, leishmaniasis, penicilliosis (His GIrLPenelope) | | | | | |
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| | | | | | | Table 4-15 Microscopic Appearance of Select Fungi and Protozoa | | | Organism | | Description | | Size (µm) | | | Histoplasma capsulatum | | Round yeast with surrounding thin, clear halo; distributed evenly within cytoplasm of histiocyte | | 2–4 | | | Leishmania spp. | | Small, grouped intracellular organisms with rod-shaped kinetoplast, no halo | | 2–4 | | | Apergillus spp. | | Septate hyphae with 45° branching, often in blood vessels | | 2–4 | | | Penicillium marneffei | | Oval to round yeast, may be intracellular or extracellular | | 3–5 | | | Sporothrix schenckii | | Round to cigar-shaped yeast, difficult to find | | 3–8 | | | Prototheca spp. | | Spherule with morula formation with numerous septations (resembles soccer ball) | | 3–11 | | | Blastomyces dermatitidis | | Thick-walled spores, characteristic broad-based budding | | 8–15 | | | Cryptococcus neoformans | | Budding yeast with prominent mucinous capsule (does not stain with H&E) | | 5–20 | | | Coccidioides immitis | | Double contoured spheres with endospores | | 10–80 | | | Mucor spp. | | Broad hyphae with 90° branching | | 10–25 | | | Paracoccidioides brasiliensis | | Characteristic buds resembling mariner’s wheel | | 5–60 | | | Rhinosporidium seeberi | | Spherule with endospores (6–10 µm) | | 250–500 | | | | | | | |
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| | Figure 4.35
A: Alternaria spp.*
B: Fusarium spp.*
C: Penicillium spp.*
*Courtesy of Sandra Arduin,
Michigan Department of
Community Health |
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