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Mycobacterial Infections

»What is the classification system of mycobacteria?
»What are the staining characteristics of mycobacteria?
»How many species of Mycobacterium cause infection in human beings?
»Name three mycobacteria in the tuberculosis complex responsible for tuberculosis.
»What is tuberculosis?
»What is the difference between a primary and secondary infection?
»Explain the route of infection in cutaneous tuberculosis.
»Who is at risk of acquiring tuberculosis?
»Describe the histopathologic hallmark of tuberculosis.
»How can one acquire primary cutaneous tuberculosis?
»Describe the clinical manifestation of primary-inoculation cutaneous tuberculosis.
»What are the different types of cutaneous tuberculosis?
»What laboratory tests are used to diagnose Mycobacterium tuberculosis?
»Is lupus vulgaris related to lupus erythematosus or lupus pernio?
»Describe the clinical manifestations of lupus vulgaris.
»Where and when does lupus vulgaris develop?
»What is scrofuloderma?
»Name the vaccination against tuberculosis. What type of vaccination is it?
»What drugs are used in the treatment of tuberculosis?
»What are the major side effects of antituberculous agents?
»What factors have led to multidrug-resistant tuberculosis?
»Are there any special treatment considerations for cutaneous tuberculosis?
»What is the mechanism of action of TNF-a in tuberculosis?
»Describe the pathogenesis of the atypical mycobacteria.
»Describe the pathogenesis of the atypical mycobacteria.
»What is a “swimming pool granuloma”?
»What is a Buruli ulcer?
»Describe the clinical manifestations of Mycobacterium avium-intracellulare complex (MAC) in both non-AIDS and AIDS patients.
»Which atypical mycobacteria are associated with mesotherapy?
»Which atypical mycobacteria are associated with tattoos?
»Which atypical mycobacteria have been associated with soft tissue fillers?
»How are infections with rapidly growing mycobacteria managed?
»What are some of the key features of Mycobacterium kansasii?

 
 
 

Which atypical mycobacteria have been associated with soft tissue fillers?

In 2002 there were two cases of M. abscessus infection following the injection of soft tissue filler. Both patients were injected with Hyacell, a product not approved by the FDA but available in South America. It had been brought illegally into the United States and was administered by an individual posing as a physician. Hyacell is a mixture of hyaluronic acid, zinc, selenium, vanadium, and unspecified “embryonic extracts.” The patients developed tender nodules and were treated with resolution using clarithromycin and prednisone.

Cohen JL: Understanding, avoiding, and managing dermal filler complications, Dermatol Surg 34(Suppl 1):S92–S99, 2008.