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Neonatal Infections

»What are the TORCHES infections in a neonate?
»Describe the cutaneous findings in neonatal herpes simplex viral (HSV) infections.
»Is neonatal herpes simplex dangerous?
»What percentage of herpes-infected neonates display skin or mucosal lesions?
»What percentage of these lesions are HSV-1, as opposed to HSV-2?
»What tests can be done to diagnose herpes infections? How should material be obtained for these tests?
»What is congenital varicella syndrome?
»What is the average age of onset of lesions in a neonate exposed to varicella perinatally? When is there an increased risk of mortality?
»What is the treatment of neonatal HSV and varicella infection?
»What is a “blueberry muffin baby”? What is the significance of this diagnosis?
»At what time during pregnancy is there the highest risk of congenital rubella following maternal infection?
»List the classic triad of congenital rubella syndrome (CRS).
»Are any precautions necessary for infants with congenital rubella syndrome at the time of hospital discharge?
»Why is human parvovirus infection important to a pregnant woman?
»Are most infants with congenital cytomegalovirus (CMV) infection symptomatic?
»What cutaneous findings are seen in congenital CMV infection?
»What clinical findings are seen in congenital Epstein-Barr virus infection?
»Describe a clinical presentation of congenital human papillomavirus infection.
»What is the risk of HIV infection transmission to an infant born from an HIV-positive mother?
»What is Hutchinson’s triad?
»Are there any other stigmata of late congenital syphilis?
»What are the physical findings of early congenital syphilis?

 
 
 

What is Hutchinson’s triad?

Interstitial keratitis, Hutchinson’s teeth, and eighth nerve deafness. These are common findings in late congenital syphilis. Interstitial keratitis is the most common lesion in this triad. It is rare before age 8 and after age 40. Both eyes are usually affected, and the corneal clouding may be spotty or diffuse. Hutchinson’s teeth are due to deficient development of the permanent teeth buds and are characterized by conical central incisors with notching of the distal free margin. Eighth nerve deafness usually occurs after interstitial keratitis, is usually bilateral, and is often preceded by tinnitus and vertigo.

Azimi P: Syphilis. In Behrman R, Kliegman R, Jenson H, editors: Nelson textbook of pediatrics, Philadelphia, 2004, WB Saunders, pp 978–982.