Muir–Torre Syndrome

  • AD, mutation in MLH1 and MSH2 (DNA mismatch repair genes) causing microsatellite instability
  • Multiple sebaceous neoplasms and keratoacanthomas
  • ↑ Risk of colon adenocarcinoma, less common GU, lung, breast or heme malignancy
   
 
Muir –Torre: think of “more” and more sebaceous neoplasms