Content

»	Soft Tissue Augmentation
	»	Introduction
		»	Overview of Common Injectable Fillers
			»	Fat
			»	Autologous
			»	Cadaver-Derived
			»	Collagen
			»	Hyaluronic Acid
			»	Poly-L-lactic Acid
			»	Silicone Oil
	»	Scientific Background
		»	Autologous Material
			»	Fat Transfer
			»	Fat Autograft Muscle Injection
			»	Cultured Human Fibroblasts
		»	Cadaver-derived Implants
			»	Acellular Allogeneic Dermis
			»	Injectable Microparticulate Acellular Allogeneic Dermis
			»	Lyophilized Human Particulate Fascia Lata
		»	Temporary
			»	Animal-Based Collagen
			»	Non-Animal-Based Collagen
			»	Hyaluronic Acid
			»	Poly-L-lactic Acid
		»	Semipermanent
			»	Synthetic Calcium Hydroxylapatite Microspheres Suspended in Aqueous Polysaccharide Gel
		»	Permanent
			»	Polymethylmethacrylate Microspheres in Denatured Bovine Collagen
			»	Silicone Oil
		»	Implants
			»	Expanded Polytetrafluoroethylene
			»	Gore-Tex
			»	Dual-Porosity Expanded Polytetrafluoroethylene
	»	Indications
	»	Patient Selection
		»	Contraindications
		»	Specific Product Contraindications
	»	References

Poly-L-lactic Acid

The vial of dry lactic acid monomers is reconstituted with bacteriostatic water to form the PLA (example: Sculptra/New-Fill). When injected into the deep dermis or dermal-subcutaneous plane, PLA causes an immediate physical improvement to the appearance. The PLA hydrogel is slowly degraded into lactic acid microspheres and carbon dioxide, thus leaving behind the crystals to stimulate collagen and nonallergic granulomatous reaction leading to dermal thickening.