Polymethylmethacrylate Microspheres in Denatured Bovine Collagen

This synthetic implant (example: Artecoll/ Artefill) is composed of polymethylmethacrylate (PMMA) microspheres suspended in 3.5% denatured bovine collagen mixed with 0.3% lidocaine. PMMA has been used in medical implants for many years, and it is found in numerous products today. The PMMA is formulated into microspheres and mixed with denatured bovine collagen and lidocaine in a phosphatebuffered saline solution. PMMA is an inert substance, well tolerated by the body, and reports of allergic reactions to it are rare [18, 28].