Neurofibromatosis
»	What are the two main forms of neurofibromatosis?
»	Outline the diagnostic criteria for NF-1.
»	Where is the gene for NF-1 located? What protein does it encode?
»	What is the earliest skin sign of NF-1?
»	What is Crowe’s sign? When does it develop?
»	When do peripheral neurofibromas appear in NF-1?
»	What is a plexiform neurofibroma?
»	What are Lisch nodules?
»	What is the most common central nervous system (CNS) tumor occurring in NF-1?
»	How common is intellectual impairment in NF-1?
»	What are the most common skeletal abnormalities in NF-1?
»	How frequently should patients with NF-1 be assessed? What should this assessment include?
»	What are the diagnostic criteria for NF-2?
»	Where is the gene for NF-2? What is the gene product?
»	What are the most common presenting symptoms of NF-2?
»	What are the skin signs of NF-2?
»	What is the ocular sign of NF-2?

Outline the diagnostic criteria for NF-1.

The diagnosis can be made if two or more of the following criteria are present:

Six or more café-au-lait macules > 5 mm in greatest diameter in prepubertal children and > 15 mm diameter in postpubertal individuals
Two or more neurofibromas of any type or one plexiform neurofibroma
Freckling in axillary or inguinal regions
Two or more Lisch nodules
Optic glioma
Distinctive osseous lesion, such as sphenoid dysplasia or thinning of long bone cortex, with or without pseudoarthrosis
First-degree relative with NF-1

National Institutes of Health Consensus Development Conference: Conference statement: neurofibromatosis, Arch Neurol 45, 575–578, 1988.