Neurofibromatosis
»	What are the two main forms of neurofibromatosis?
»	Outline the diagnostic criteria for NF-1.
»	Where is the gene for NF-1 located? What protein does it encode?
»	What is the earliest skin sign of NF-1?
»	What is Crowe’s sign? When does it develop?
»	When do peripheral neurofibromas appear in NF-1?
»	What is a plexiform neurofibroma?
»	What are Lisch nodules?
»	What is the most common central nervous system (CNS) tumor occurring in NF-1?
»	How common is intellectual impairment in NF-1?
»	What are the most common skeletal abnormalities in NF-1?
»	How frequently should patients with NF-1 be assessed? What should this assessment include?
»	What are the diagnostic criteria for NF-2?
»	Where is the gene for NF-2? What is the gene product?
»	What are the most common presenting symptoms of NF-2?
»	What are the skin signs of NF-2?
»	What is the ocular sign of NF-2?

Where is the gene for NF-1 located? What protein does it encode?

The NF-1 gene is a large gene mapping to chromosome 17q11.2. It encodes a protein called neurofibromin, which has a role in tumor suppression.