How is classic polyarteritis nodosa different from Kawasaki disease? Both disorders affect medium-sized vessels. PAN produces a necrotizing inflammation of medium-sized and/or small arteries without producing glomerulonephritis or vasculitis in arterioles, capillaries, or venules. Patients with Kawasaki disease are most often children with mucocutaneous lymph node syndrome (adenopathy, glossitis, cheilitis, conjunctivitis, etc.) with arteritis involving large (often resulting in coronary arteritis, coronary artery aneurysms, and myocardial infarctions), medium-sized, and small arteries. |
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