Name the various types of amyloidosis.

Amyloidosis may be classified according to clinical presentation and type of amyloid fibril protein deposition (Table 16-1). The amyloid in the macular and lichenoid variants is derived from degenerated tonofilaments of keratinocytes. Nodular amyloidosis is formed from light-chain–derived AL protein produced locally by plasma cells. It cannot be distinguished from primary systemic amyloidosis, and therefore, systemic disease should be excluded in all patients with nodular amyloidosis. There are also rare forms of hereditary systemic amyloidoses that have less frequent skin manifestations.

Table 16-1. Classification of Amyloidosis
	CLINICAL DISORDER		AMYLOID PROTEIN PRECURSOR		AMYLOID PROTEIN
	Primary systemic amyloidosis		Immunoglobulin light chain		AL
	Myeloma-associated amyloidosis		Immunoglobulin light chain		AL
	Secondary systemic amyloidosis		Serum amyloid A lipoprotein		AA
	Primary localized cutaneous amyloidosis
	Macular amyloidosis		Keratinocyte tonofilaments		-
	Lichen amyloidosis		Keratinocyte tonofilaments		-
	Nodular amyloidosis		Immunoglobulin light chain (produced locally by plasma cells)		AL