How is hypertrophic osteoarthropathy related to clubbing? Clubbing may occur in association with hypertrophic osteoarthropathy, an uncommon but important entity. It consists of simple clubbing (including the toes), hypertrophy of the upper and lower extremities, peripheral neurovascular disease, acute burning bone pain, joint problems, and muscle weakness. More importantly, when complete, it is associated 90% of the time with malignant tumors of the chest. |
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