« Back to Cutaneous Manifestations of Internal Diseases

Cutaneous Manifestations of Internal Malignancy

»	List the five criteria that establish an association between a skin disease and internal malignancy.
»	What is Sweet’s syndrome?
»	Describe the cutaneous lesions of Sweet’s syndrome.
»	Are any laboratory abnormalities found in Sweet’s syndrome?
»	What cancers are associated with Sweet’s syndrome?
»	Describe the clinical appearance of acanthosis nigricans.
»	What clinical disease states are associated with acanthosis nigricans?
»	What is necrolytic migratory erythema?
»	What is hypertrichosis lanuginosa?
»	What is Trousseau’s sign?
»	Describe the classical skin lesions of dermatomyositis.
»	Is dermatomyositis associated with internal malignancy?
»	What are the three components of Sézary’s syndrome?
»	What is paraneoplastic pemphigus?
»	Discuss the laboratory findings in patients with paraneoplastic pemphigus.
»	What is the characteristic finding in erythema gyratum repens?
»	How do the lesions in Bazex syndrome (acrokeratosis paraneoplastica) progress?
»	Where does Paget’s disease most commonly occur?
»	Which disorder of protein metabolism is associated with skin lesions and malignancy?
»	List the autosomal dominant diseases that have prominent skin findings and internal cancer.
»	Describe the cutaneous features of Gardner’s syndrome.
»	What are the clinical findings in Cowden’s syndrome (multiple hamartoma syndrome)?
»	When do the characteristic skin lesions of Peutz-Jeghers syndrome appear?
»	How does multiple mucosal neuroma syndrome typically present?
»	What is Torre’s syndrome (Muir-Torre’s syndrome)?
»	Is the sign of Leser-Trélat (eruptive seborrheic keratoses) associated with internal malignancy?
»	Is dry scaly skin associated with internal malignancy?
»	Which recessively inherited diseases have skin findings and associated internal malignancy?
»	Can pyoderma gangrenosum be associated with internal malignancy?
»	What is erythromelalgia?
»	Can pruritus be a sign of malignancy?
»	Is vasculitis associated with malignancy?
»	What is multicentric reticulohistiocytosis?
»	What is carcinoid syndrome? Does it have prognostic significance?
»	What is FAMM syndrome?

Which recessively inherited diseases have skin findings and associated internal malignancy?

See Table 35-2.

Table 35-2. Recessively Inherited Diseases with Skin Findings and Malignancy
	DISORDER	INHERITANCE	CLINICAL FINDINGS	CANCER	AFFECTED GENE
	Wiskott-Aldrich syndrome	X-linked recessive	Chronic dermatitis Thrombocytopenia Recurrent infections	Lymphoma, especially non-Hodgkin’s	WAS
	Bloom’s syndrome	Autosomal recessive	Photosensitivity Telangiectasia of sun-exposed skin Short stature Decreased serum immunoglobulins Recurrent infections Sister chromatid exchange	Lymphomas Leukemias	RecQ3
	Ataxia-telangiectasia (Louis-Bar syndrome)	Autosomal recessive	Progressive cerebellar ataxia Telangiectasia Recurrent sinus and pulmonary infections Decreased/absent serum IgA	Lymphomas (increased cancer risk also seen in heterozygotes)	ATM
	Dyskeratosis congenita	X-linked recessive Autosomal dominant	Skin atrophy and hyperpigmentation Nail dystrophy Oral precancerous leukokeratosis	Oral cancers Other malignancies	DKC1 TERC
	WAS, Wiskott-Aldrich syndrome; RecQ3, DNA helicase Rec Q protein-like-3; ATM, ataxia telangiectasia mutated; DKC1, dyskerin; TERC, telomerase RNA component.