Which hormones have the greatest effect on sebaceous glands and hair?

The androgens. Androgens at the time of puberty induce sebaceous gland activity and the development of acne. Excess androgen in women may cause acne, hirsutism (increased facial hair), and/or alopecia. Associated signs may include hyperpigmentation of genital and areolar skin and clitoromegaly. Possible causes of hirsutism and acne in women include adrenal and ovarian tumors, prolactin-producing pituitary tumors, polycystic ovarian disease, adrenal enzyme deficiencies, and familial acne and hirsutism that may be related to increased end-organ sensitivity to normal circulating levels of androgens. Most acne and hirsutism in women is benign and familial. Screening tests for tumors include serum prolactin; dehydroepiandrosterone sulfate (DHEAS), which is an androgen produced by the adrenal glands; and free testosterone.