What are the onset of action and the duration of action of the most commonly used local anesthetics in skin surgery? The amides, especially lidocaine and bupivacaine, are the most commonly used local anesthetics in skin surgery. Lidocaine has an onset of action of approximately 5 minutes. Its potency and duration of action is significantly greater than that of procaine. When combined with epinephrine, it provides anesthesia for 60 to 400 minutes (average: 180 minutes), compared to 30 to 120 minutes (average: 90 minutes) without epinephrine. Bupivacaine, which is more potent than lidocaine, has an onset of action of approximately 8 minutes, and an average duration of action of 120 to 140 minutes without epinephrine, and 240 to 480 minutes with epinephrine. This makes it an ideal agent for regional nerve blocks and Mohs micrographic surgery. |
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