What concentrations of epinephrine are the most effective for skin surgery? What is the safe maximum total dose? Epinephrine, 1:100,000 (1 mg/100 mL), is the most commonly used concentration in skin surgery, although a concentration of 1:200,000 is just as effective. Always try to use the lowest concentration possible. Dilutions of up to 1:500,000 are still effective. Concentrations of 1:50,000 or higher may induce tissue necrosis due to prolonged ischemia. The safe, maximum dose of epinephrine given at any one time is 0.2 mg for an adult. Onset of action may be as long as 15 minutes. |
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