What are the most important advantages and disadvantages of povidone-iodine and chlorhexidine gluconate?Povidone-iodine has a relatively slow onset of action, and its activity ends after it has dried. It is inactivated by contact with blood and other organic substances. It is also toxic to the cells within an open wound, with resultant delayed wound healing. Chlorhexidine gluconate has a much faster onset of action and maintains its antimicrobial activity for up to 6 hours. It should not be used for preoperative skin preparation on the head and neck, due to possible ototoxicity and corneal erosions and opacifications with inadvertent exposure at these sites. Povidone-iodine is a better choice for the head and neck. However, chlorhexidine gluconate is preferable to povidone-iodine for the trunk and extremities, due to its more rapid onset of action, broader spectrum of antimicrobial coverage, and longer duration of activity. |
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