What are the symptoms and signs of lidocaine toxicity and how is it treated? The effects on the central nervous system can be divided into early (serum lidocaine levels of 1 to 5 gm/mL), mid (5 to 12 gm/mL), and late (20 to 25 mg/kg) effects. - Early effects: Talkativeness, metallic taste, diplopia, tinnitus, lightheadedness, nausea, circumoral pallor, and vomiting. Observation is the only treatment necessary. Recognition of early lidocaine toxicity is of paramount importance.
- Mid effects: Nystagmus, slurred speech, hallucinations, muscle twitching, facial/hand tremors, and seizures. Treatment includes observation, oxygen, and intravenous diazepam for seizures.
- Late effects: Apnea, coma. Cardiovascular effects include bradycardia, hypotension, atrioventricular block, ventricular arrhythmias, hypoxia, and acidosis. Treatment is directed accordingly, per advanced cardiac life support (ACLS) protocols.
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